Sarcophaguses are used by Engineers in the Derelict's Orrery aboard craft on LV223. Four Sarcophaguses surround the Derelict's Orrery around a pilot's chair and cannon mechanism which rises from beneath the floor. These act as stasis units capable of keeping a Engineer alive for a great length of time, with tubes supplying oxygen and nitrogen connecting to the Engineers' bio-suit.
David first finds the Engineer when journeying into the unsurveyed area of the Alien Temple. Later David, Weyland, Sheppard, Ford, and Shaw awaken the Last Engineer from his Sarcophagus causing the Engineer to start killing the crew.